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Article

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2017

Trumble Benjamin C, Stieglitz Jonathan, Blackwell Aaron D, Allayee Hooman, Beheim Bret, Finch Caleb E, Gurven Michael, Kaplan Hillard

Abstract excerpt

The apolipoprotein E4 (E4) allele is present worldwide, despite its associations with higher risk of cardiovascular morbidity, accelerated cognitive decline during aging, and Alzheimer's disease (AD). The E4 allele is especially prevalent in some tropical regions with a high parasite burden. Equatorial populations also face a potential dual burden of high E4 prevalence combined with parasitic infections that can...

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Identifiers

PMID: 28031319
DOI: 10.1096/fj.201601084R
PMCID: PMC5349792

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