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Article

The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish.

Scientific reports - 27 Sept 2021

Chebli Jasmine, Rahmati Maryam, Lashley Tammaryn, Edeman Brigitta, Oldfors Anders, Zetterberg Henrik, Abramsson Alexandra

Abstract excerpt

Amyloid precursor protein (APP) is expressed in many tissues in human, mice and in zebrafish. In zebrafish, there are two orthologues, Appa and Appb. Interestingly, some cellular processes associated with APP overlap with cilia-mediated functions. Whereas the localization of APP to primary cilia of in vitro-cultured cells has been reported, we addressed the presence of APP in motile and in non-motile sensory...

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Identifiers

PMID: 34580355
DOI: 10.1038/s41598-021-98487-7
PMCID: PMC8476544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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