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Article

Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth.

PloS one - 1 Jan 2012

Song Ping, Pimplikar Sanjay W

Abstract excerpt

Amyloid precursor protein (APP) plays a pivotal role in Alzheimer's disease (AD) pathogenesis, but its normal physiological functions are less clear. Combined deletion of the APP and APP-like protein 2 (APLP2) genes in mice results in post-natal lethality, suggesting that APP performs an essential, if redundant, function during embryogenesis. We previously showed that injection of antisense morpholino to reduce...

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Share to Motor Neurons
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22545081
DOI: 10.1371/journal.pone.0034209
PMCID: PMC3335837

Genes

APP
APLP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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