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Article

Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons.

Neuron - 10 Jun 2004

Tsujikawa Motokazu, Malicki Jarema

Abstract excerpt

Cilia play diverse roles in vertebrate and invertebrate sensory neurons. We show that a mutation of the zebrafish oval (ovl) locus affects a component of the ciliary transport (IFT) mechanism, the IFT88 polypeptide. In mutant retina, cilia are generated but not maintained, producing the absence of photoreceptor outer segments. A loss of cilia also occurs in auditory hair cells and olfactory sensory neurons. In...

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Source

Identifiers

PMID: 15182712
DOI: 10.1016/s0896-6273(04)00268-5

Genes

IFT88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons.PMID 15182712Read ↗

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Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport.Semantic proximity Read ↗

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<i>Ift172</i> conditional knockout mice exhibit rapid retinal degeneration and protein trafficking defectsSemantic proximity Read ↗

Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins.Semantic proximity Read ↗

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