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Article

Histotype-Dependent Oligodendroglial PrP Pathology in Sporadic CJD: A Frequent Feature of the M2C "Strain".

Viruses - 9 Sept 2021

Gelpi Ellen, Klotz Sigrid, Vidal-Robau Nuria, Ricken Gerda, Regelsberger Günther, Ströbel Thomas, Kalev Ognian, Leoni Marlene, Budka Herbert, Kovacs Gabor G

Abstract excerpt

In sporadic Creutzfeldt-Jakob disease, molecular subtypes are neuropathologically well identified by the lesioning profile and the immunohistochemical PrPd deposition pattern in the grey matter (histotypes). While astrocytic PrP pathology has been reported in variant CJD and some less frequent histotypes (e.g., MV2K), oligodendroglial pathology has been rarely addressed. We assessed a series of sCJD cases with...

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Identifiers

PMID: 34578377
DOI: 10.3390/v13091796
PMCID: PMC8473396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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