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Article

Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics.

Brain : a journal of neurology - 1 Oct 2009

Cali Ignazio, Castellani Rudolph, Alshekhlee Amer, Cohen Yvonne, Blevins Janis, Yuan Jue, Langeveld Jan P M, Parchi Piero, Safar Jiri G, Zou Wen-Quan, Gambetti Pierluigi

Abstract excerpt

Five phenotypically distinct subtypes have been identified in sporadic Creutzfeldt-Jakob disease (sCJD), based on the methionine/valine polymorphic genotype of codon 129 of the prion protein (PrP) gene and the presence of either one of the two protease K-resistant scrapie prion protein (PrP(Sc)) types identified as 1 and 2. The infrequent co-existence of both PrP(Sc) types in the same case has been known for a...

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Identifiers

PMID: 19734292
DOI: 10.1093/brain/awp196
PMCID: PMC2766234

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Source receipt: pubmed, retrieved 7 Sept 2026.

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