Article
Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification.
Acta neuropathologica - 1 Nov 2009
Parchi Piero, Strammiello Rosaria, Notari Silvio, Giese Armin, Langeveld Jan P M, Ladogana Anna, Zerr Inga, Roncaroli Federico, Cras Patrich, Ghetti Bernardino, Pocchiari Maurizio, Kretzschmar Hans, Capellari Sabina
Abstract excerpt
Six subtypes of sporadic Creutzfeldt-Jakob disease with distinctive clinico-pathological features have been identified largely based on two types of the abnormal prion protein, PrP(Sc), and the methionine (M)/valine (V) polymorphic codon 129 of the prion protein. The existence of affected subjects showing mixed phenotypic features and concurrent PrP(Sc) types has been reported but with inconsistencies among...
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