Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel histotypes of sporadic Creutzfeldt-Jakob disease linked to 129MV genotype.

Acta neuropathologica communications - 31 Aug 2023

Cracco Laura, Puoti Gianfranco, Cornacchia Antonio, Glisic Katie, Lee Seong-Ki, Wang Zerui, Cohen Mark L, Appleby Brian S, Cali Ignazio

Abstract excerpt

The MV1 and MV2 subtypes of sporadic Creutzfeldt-Jakob disease (sCJD) are linked to the heterozygous methionine (M)/valine (V) polymorphism at codon 129 of the prion protein (PrP) gene. MV2 is phenotypically heterogeneous, whereas MV1, due to its low prevalence, is one of the least well characterized subtypes. In this study, we investigated the biochemical properties of PrPSc and phenotypic expression of cases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creutzfeldt-Jakob Syndrome
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Plaque, Amyloid

Share to Prion Proteins

Share to Prions

Source

Open in PubMed Open full text

Identifiers

PMID: 37653534
DOI: 10.1186/s40478-023-01631-9
PMCID: PMC10469800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel histotypes of sporadic Creutzfeldt-Jakob disease linked to 129MV genotype.PMID 37653534Read ↗

Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein.Semantic proximity Read ↗

Phenotypic diversity of genetic Creutzfeldt-Jakob disease: a histo-molecular-based classification.Semantic proximity Read ↗

Defining the phenotypic spectrum of sporadic Creutzfeldt-Jakob disease MV2K: the kuru plaque type.Semantic proximity Read ↗

Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification.Semantic proximity Read ↗

The Phenotypic Spectrum of Sporadic Creutzfeldt-Jakob Disease Cortical Subtype.Semantic proximity Read ↗

A novel subtype of sporadic Creutzfeldt-Jakob disease with PRNP codon 129MM genotype and PrP plaques.Semantic proximity Read ↗

A case of MV2K subtype of sporadic Creutzfeldt-Jakob disease with florid-like plaques: Similarities and differences to variant Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Histotype-Dependent Oligodendroglial PrP Pathology in Sporadic CJD: A Frequent Feature of the M2C "Strain".Semantic proximity Read ↗

Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics.Semantic proximity Read ↗

A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease.Semantic proximity Read ↗

MRI lesion profiles in sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

PrP mRNA and protein expression in brain and PrP(c) in CSF in Creutzfeldt-Jakob disease MM1 and VV2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.