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Article

Regional pattern of microgliosis in sporadic Creutzfeldt-Jakob disease in relation to phenotypic variants and disease progression.

Neuropathology and applied neurobiology - 1 Oct 2018

Franceschini A, Strammiello R, Capellari S, Giese A, Parchi P

Abstract excerpt

AIMS: The aim of this study was to describe the regional profiles of microglial activation in sporadic Creutzfeldt-Jakob disease (sCJD) subtypes and analyse the influence of prion strain, disease duration and codon 129 genotype. METHODS: We studied the amount/severity and distribution of activated microglia, protease-resistant prion protein (PrPSc ) spongiform change, and astrogliosis in eight regions of 57...

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Identifiers

PMID: 29345730
DOI: 10.1111/nan.12461

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MVK
PRNP

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