Article
PrP mRNA and protein expression in brain and PrP(c) in CSF in Creutzfeldt-Jakob disease MM1 and VV2.
Prion - 1 Jan 2000
Llorens Franc, Ansoleaga Belén, Garcia-Esparcia Paula, Zafar Saima, Grau-Rivera Oriol, López-González Irene, Blanco Rosi, Carmona Margarita, Yagüe Jordi, Nos Carlos, Del Río José Antonio, Gelpí Ellen, Zerr Inga, Ferrer Isidre
Abstract excerpt
Creutzfeldt-Jakob disease (CJD) is a heterogenic neurodegenerative disorder associated with abnormal post-translational processing of cellular prion protein (PrP(c)). CJD displays distinctive clinical and pathological features which correlate with the genotype at the codon 129 (methionine or valine: M or V respectively) in the prion protein gene and with size of the protease-resistant core of the abnormal prion...
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