Article
Phenotypic diversity of genetic Creutzfeldt-Jakob disease: a histo-molecular-based classification.
Acta neuropathologica - 1 Oct 2021
Baiardi Simone, Rossi Marcello, Mammana Angela, Appleby Brian S, Barria Marcelo A, Calì Ignazio, Gambetti Pierluigi, Gelpi Ellen, Giese Armin, Ghetti Bernardino, Herms Jochen, Ladogana Anna, Mikol Jacqueline, Pal Suvankar, Ritchie Diane L, Ruf Viktoria, Windl Otto, Capellari Sabina, Parchi Piero
Abstract excerpt
The current classification of sporadic Creutzfeldt-Jakob disease (sCJD) includes six major clinicopathological subtypes defined by the physicochemical properties of the protease-resistant core of the pathologic prion protein (PrPSc), defining two major PrPSc types (i.e., 1 and 2), and the methionine (M)/valine (V) polymorphic codon 129 of the prion protein gene (PRNP). How these sCJD subtypes relate to the...
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