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Article

Sporadic Creutzfeldt-Jakob Disease MM1+2C and MM1 are Identical in Transmission Properties.

Brain pathology (Zurich, Switzerland) - 1 Jan 2016

Kobayashi Atsushi, Matsuura Yuichi, Iwaki Toru, Iwasaki Yasushi, Yoshida Mari, Takahashi Hitoshi, Murayama Shigeo, Takao Masaki, Kato Shinsuke, Yamada Masahito, Mohri Shirou, Kitamoto Tetsuyuki

Abstract excerpt

The genotype (methionine, M or valine, V) at polymorphic codon 129 of the PRNP gene and the type (1 or 2) of abnormal prion protein in the brain are the major determinants of the clinicopathological features of sporadic Creutzfeldt-Jakob disease (CJD), thus providing molecular basis for classification of sporadic CJD, that is, MM1, MM2, MV1, MV2, VV1 or VV2. In addition to these "pure" cases, "mixed" cases...

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PMID: 25851836
DOI: 10.1111/bpa.12264
PMCID: PMC8028929

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PRNP

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Source receipt: pubmed, retrieved 7 Sept 2026.

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