Article
Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature.
Acta neuropathologica communications - 23 Nov 2017
Rossi Marcello, Saverioni Daniela, Di Bari Michele, Baiardi Simone, Lemstra Afina Willemina, Pirisinu Laura, Capellari Sabina, Rozemuller Annemieke, Nonno Romolo, Parchi Piero
Abstract excerpt
Amyloid plaques formed by abnormal prion protein (PrPSc) aggregates occur with low frequency in Creutzfeldt-Jakob disease, but represent a pathological hallmark of three relatively rare disease histotypes, namely variant CJD, sporadic CJDMV2K (methionine/valine at PRNP codon 129, PrPSc type 2 and kuru-type amyloid plaques) and iatrogenic CJDMMiK (MM at codon 129, PrPSc of intermediate type and kuru plaques)....
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