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Article

Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.

Immunity - 20 Jun 2017

Dulberger Charles L, McMurtrey Curtis P, Hölzemer Angelique, Neu Karlynn E, Liu Victor, Steinbach Adriana M, Garcia-Beltran Wilfredo F, Sulak Michael, Jabri Bana, Lynch Vincent J, Altfeld Marcus, Hildebrand William H, Adams Erin J

Abstract excerpt

Evidence is mounting that the major histocompatibility complex (MHC) molecule HLA-F (human leukocyte antigen F) regulates the immune system in pregnancy, infection, and autoimmunity by signaling through NK cell receptors (NKRs). We present structural, biochemical, and evolutionary analyses demonstrating that HLA-F presents peptides of unconventional length dictated by a newly arisen mutation (R62W) that has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28636952
DOI: 10.1016/j.immuni.2017.06.002
PMCID: PMC5523829

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