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Article

Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors.

Biomolecules - 15 Sept 2021

Lee Sangmin

Abstract excerpt

The calcitonin and amylin receptors (CTR and AMY receptors) are the drug targets for osteoporosis and diabetes treatment, respectively. Salmon calcitonin (sCT) and pramlintide were developed as peptide drugs that activate these receptors. However, next-generation drugs with improved receptor binding profiles are desirable for more effective pharmacotherapy. The extracellular domain (ECD) of CTR was reported as...

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Share to Amino Acid Sequence
Share to Calcitonin
Share to Extracellular Space

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Calcitonin

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Identifiers

PMID: 34572577
DOI: 10.3390/biom11091364
PMCID: PMC8466238

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