Article
A structural basis for amylin receptor phenotype.
Science (New York, N.Y.) - 25 Mar 2022
Cao Jianjun, Belousoff Matthew J, Liang Yi-Lynn, Johnson Rachel M, Josephs Tracy M, Fletcher Madeleine M, Christopoulos Arthur, Hay Debbie L, Danev Radostin, Wootten Denise, Sexton Patrick M
Abstract excerpt
Amylin receptors (AMYRs) are heterodimers of the calcitonin (CT) receptor (CTR) and one of three receptor activity-modifying proteins (RAMPs), AMY1R, AMY2R, and AMY3R. Selective AMYR agonists and dual AMYR/CTR agonists are being developed as obesity treatments; however, the molecular basis for peptide binding and selectivity is unknown. We determined the structure and dynamics of active AMYRs with amylin, AMY1R...
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