Article

An insight into the activation mechanism of the calcitonin-gene-related peptide receptor

2010-01-01

Abstract excerpt

The calcitonin-gene-related peptide (CGRP) receptor is unique among G-protein coupled receptors (GPCRs) as it consists of at least three proteins: calcitonin receptor like receptor (CLR), receptor activity modifying protein (RAMP)1 and receptor component protein (RCP). An endogenous agonist for this curious receptor is aCGRP, which is a sensory nerve-derived peptide made up of 37 amino acids. aCGRP acts as a poten...

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Literature Corpus work: 15a89296-24e5-57f2-b32e-30d5397538be
DOI: 10.48780/publications.aston.ac.uk.00015277

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