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Article

Inhibiting Human Calcitonin Fibril Formation with Its Most Relevant Aggregation-Resistant Analog.

The journal of physical chemistry. B - 5 Dec 2019

Chen Yi-Ting, Hu Kai-Wei, Huang Bo-Jie, Lai Chian-Hui, Tu Ling-Hsien

Abstract excerpt

The most common obstacles to the development of therapeutic polypeptides are peptide stability and aggregation. Human calcitonin (hCT) is a 32-residue hormone polypeptide secreted from the C-cells of the thyroid gland and is responsible for calcium and phosphate regulation in the blood. hCT reduces calcium levels by inhibiting the activity of osteoclasts, which are bone cells that are mainly responsible for...

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Identifiers

PMID: 31692350
DOI: 10.1021/acs.jpcb.9b08514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibiting Human Calcitonin Fibril Formation with Its Most Relevant Aggregation-Resistant Analog.PMID 31692350Read ↗

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Both single mutation and molecular conjugation on the mutant prevent calcitonin from forming amyloid fibrils.Semantic proximity Read ↗

Molecular Insights into the Effects of F16L and F19L Substitutions on the Conformation and Aggregation Dynamics of Human Calcitonin.Semantic proximity Read ↗

Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors.Semantic proximity Read ↗

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