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Article

Activity of pramlintide, rat and human amylin but not Aβ1-42 at human amylin receptors.

Endocrinology - 1 Jan 2014

Gingell Joseph J, Burns Erica R, Hay Debbie L

Abstract excerpt

Amylin is a neuroendocrine hormone involved in glucose regulation. An amylin analog, pramlintide, is used to treat insulin-requiring diabetes. Its anorexigenic actions give it potential as an obesity treatment. There are 3 amylin receptors (AMY1, AMY2, AMY3), comprising the calcitonin receptor and receptor activity-modifying proteins 1, 2, and 3, respectively. The pharmacology of pramlintide at each subtype has...

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PMID: 24169554
DOI: 10.1210/en.2013-1658

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