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Article

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.

Molecular cell - 18 Jun 2015

Booe Jason M, Walker Christopher S, Barwell James, Kuteyi Gabriel, Simms John, Jamaluddin Muhammad A, Warner Margaret L, Bill Roslyn M, Harris Paul W, Brimble Margaret A, Poyner David R, Hay Debbie L, Pioszak Augen A

Abstract excerpt

Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascular and lymphatic systems. How peptides selectively bind GPCR:RAMP complexes is unknown. We report crystal...

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Share to Calcitonin Gene-Related Peptide
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Crystallography, X-Ray

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Identifiers

PMID: 25982113
DOI: 10.1016/j.molcel.2015.04.018
PMCID: PMC4504005

Genes

RAMP1
RAMP2

Provenance

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