Article

Amylin receptor subunit interactions are modulated by agonists and determine signaling

2024-10-09

Abstract excerpt

Three amylin receptors (AMYRs) mediate the metabolic actions of the peptide hormone amylin and are drug targets for diabetes and obesity. AMY 1 R, AMY 2 R, and AMY 3 R are heterodimers consisting of the G protein-coupled calcitonin receptor (CTR) paired with a RAMP1, -2, or -3 accessory subunit, respectively, which increases amylin potency. Little is known about AMYR subunit interactions and their role in signa...

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Literature Corpus work: aca7ad78-e7d0-5474-87fe-eddc57389f17
DOI: 10.1101/2024.10.09.617487

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