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Article

N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.

Biochemistry - 5 Jul 2017

Lee Sang-Min, Booe Jason M, Gingell Joseph J, Sjoelund Virginie, Hay Debbie L, Pioszak Augen A

Abstract excerpt

The calcitonin receptor (CTR) is a class B G protein-coupled receptor that is activated by the peptide hormones calcitonin and amylin. Calcitonin regulates bone remodeling through CTR, whereas amylin regulates blood glucose and food intake by activating CTR in complex with receptor activity-modifying proteins (RAMPs). These receptors are targeted clinically for the treatment of osteoporosis and diabetes. Here, we...

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Share to Acetylglucosamine
Share to Asparagine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Islet Amyloid Polypeptide

Share to Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase

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Share to Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase

Share to Receptors, Calcitonin

Source

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Identifiers

PMID: 28614667
DOI: 10.1021/acs.biochem.7b00256
PMCID: PMC5551398

Genes

ECD
RAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.PMID 28614667Read ↗

Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors.Semantic proximity Read ↗

A structural basis for amylin receptor phenotype.Semantic proximity Read ↗

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.Semantic proximity Read ↗

Amylin receptor subunit interactions are modulated by agonists and determine signalingSemantic proximity Read ↗

Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling.Semantic proximity Read ↗

Receptor activity modifying proteins.Semantic proximity Read ↗

A critical role for the short intracellular C terminus in receptor activity-modifying protein function.Semantic proximity Read ↗

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonistsSemantic proximity Read ↗

The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors.Semantic proximity Read ↗

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.Semantic proximity Read ↗

N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation.Semantic proximity Read ↗

Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product.Semantic proximity Read ↗

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