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Article

Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations.

Protein science : a publication of the Protein Society - 1 Apr 2024

Chang Yu-Pei, Pan Pei-Chun, Tu Ling-Hsien

Abstract excerpt

The therapeutic efficacy of peptide-based drugs is commonly hampered by the intrinsic propensity to aggregation. A notable example is human calcitonin (hCT), a peptide hormone comprising 32 amino acids, which is synthesized and secreted by thyroid gland parafollicular cells (C cells). This hormone plays a vital role in regulating blood calcium levels and upholding bone integrity. Despite its physiological...

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PMID: 38501491
DOI: 10.1002/pro.4952
PMCID: PMC10949316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations.PMID 38501491Read ↗

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