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The regulation of ferroptosis by MESH1 through the activation of the integrative stress response

22 Jul 2021

Abstract excerpt

All organisms exposed to metabolic and environmental stresses have developed various stress adaptive strategies to maintain homeostasis. The main bacterial stress survival mechanism is the stringent response triggered by the accumulation "alarmone" (p)ppGpp, whose level is regulated by RelA and SpoT. While metazoan genomes encode MESH1 (Metazoan SpoT Homolog 1) with ppGpp hydrolase activity, neither ppGpp nor the...

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PMID: 34294679
DOI: 10.1038/s41419-021-04018-7

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