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Article

Microglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls.

Translational psychiatry - 23 Sept 2021

Corley Emma, Holleran Laurena, Fahey Laura, Corvin Aiden, Morris Derek W, Donohoe Gary

Abstract excerpt

Changes in immune function are associated with variance in cognitive functioning in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we examined whether schizophrenia risk-associated microglial genes (measured via polygenic score analysis) explained variation in cognition in patients with schizophrenia and controls (n = 1,238) and tested whether grey matter mediated this...

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Identifiers

PMID: 34556640
DOI: 10.1038/s41398-021-01616-z
PMCID: PMC8460789

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