Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic insights into the shared and distinct genetic architecture of cognitive function and schizophrenia.

Scientific reports - 4 Jul 2024

Wootton Olivia, Shadrin Alexey A, Bjella Thomas, Smeland Olav B, van der Meer Dennis, Frei Oleksandr, O'Connell Kevin S, Ueland Torill, Andreassen Ole A, Stein Dan J, Dalvie Shareefa

Abstract excerpt

Cognitive impairment is a major determinant of functional outcomes in schizophrenia, however, understanding of the biological mechanisms underpinning cognitive dysfunction in the disorder remains incomplete. Here, we apply Genomic Structural Equation Modelling to identify latent cognitive factors capturing genetic liabilities to 12 cognitive traits measured in the UK Biobank. We identified three broad factors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognition
Share to Cognitive Dysfunction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Genomics

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Schizophrenia

Share to Schizophrenic Psychology

Source

Open in PubMed Open full text

Identifiers

PMID: 38961113
DOI: 10.1038/s41598-024-66085-y
PMCID: PMC11222449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic insights into the shared and distinct genetic architecture of cognitive function and schizophrenia.PMID 38961113Read ↗

Genetic Influences on Cognitive Dysfunction in Schizophrenia.Semantic proximity Read ↗

How can genetics help understand the relationship between cognitive dysfunction and schizophrenia?Semantic proximity Read ↗

Impaired intellect and memory: a missing link between genetic risk and schizophrenia?Semantic proximity Read ↗

Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function.Semantic proximity Read ↗

Polygenic Risk Scores Shed Light on the Relationship between Schizophrenia and Cognitive Functioning: Review and Meta-AnalysisSemantic proximity Read ↗

Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).Semantic proximity Read ↗

Genome-wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorder.Semantic proximity Read ↗

The Relationship Between Polygenic Risk Scores and Cognition in SchizophreniaSemantic proximity Read ↗

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia.Semantic proximity Read ↗

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.Semantic proximity Read ↗

Cognitive intermediate phenotype and genetic risk for psychosis.Semantic proximity Read ↗

Splitting schizophrenia: divergent cognitive and educational outcomes revealed by genomic structural equation modelling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.