Article
MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls.
Translational psychiatry - 24 Jan 2017
Cosgrove D, Harold D, Mothersill O, Anney R, Hill M J, Bray N J, Blokland G, Petryshen T, Richards A, Mantripragada K, Owen M, O'Donovan M C, Gill M, Corvin A, Morris D W, Donohoe G
Abstract excerpt
Variants at microRNA-137 (MIR137), one of the most strongly associated schizophrenia risk loci identified to date, have been associated with poorer cognitive performance. As microRNA-137 is known to regulate the expression of ~1900 other genes, including several that are independently associated with schizophrenia, we tested whether this gene set was also associated with variation in cognitive performance. Our...
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