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Article

Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts.

Biological psychiatry - 1 Jan 2024

Parker Nadine, Cheng Weiqiu, Hindley Guy F L, O'Connell Kevin S, Karthikeyan Sandeep, Holen Børge, Shadrin Alexey A, Rahman Zillur, Karadag Naz, Bahrami Shahram, Lin Aihua, Steen Nils Eiel, Ueland Thor, Aukrust Pål, Djurovic Srdjan, Dale Anders M, Smeland Olav B, Frei Oleksandr, Andreassen Ole A

Abstract excerpt

BACKGROUND: For many brain disorders, a subset of patients jointly exhibit alterations in cortical brain structure and elevated levels of circulating immune markers. This may be driven in part by shared genetic architecture. Therefore, we investigated the phenotypic and genetic associations linking global cortical surface area and thickness with blood immune markers (i.e., white blood cell counts and plasma...

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Identifiers

PMID: 37348803
DOI: 10.1016/j.biopsych.2023.06.008
PMCID: PMC11684752

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