Article
Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes.
Schizophrenia bulletin - 1 Jul 2015
Ohi Kazutaka, Hashimoto Ryota, Ikeda Masashi, Yamamori Hidenaga, Yasuda Yuka, Fujimoto Michiko, Umeda-Yano Satomi, Fukunaga Masaki, Fujino Haruo, Watanabe Yoshiyuki, Iwase Masao, Kazui Hiroaki, Iwata Nakao, Weinberger Daniel R, Takeda Masatoshi
Abstract excerpt
Cognitive impairments are a core feature in patients with schizophrenia. These deficits could serve as effective tools for understanding the genetic architecture of schizophrenia. This study investigated whether genetic variants associated with cognitive impairments aggregate in functional gene networks related to the pathogenesis of schizophrenia. Here, genome-wide association studies (GWAS) of a range of...
Topics
- Adult
- Cognition Disorders
- Female
- Gene Regulatory Networks
- Genome-Wide Association Study
- Humans
- Male
- Middle Aged
- Phenotype
- Polymorphism, Single Nucleotide