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Article

Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or Severity.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2022

Omer Nurit, Giladi Nir, Gurevich Tanya, Bar-Shira Anat, Gana-Weisz Mali, Glinka Tal, Goldstein Orly, Kestenbaum Meir, Cedarbaum Jesse M, Mabrouk Omar S, Fraser Kyle B, Shirvan Julia C, Orr-Urtreger Avi, Mirelman Anat, Thaler Avner

Abstract excerpt

BACKGROUND: Mutations in the GBA gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are risk factors for Parkinson's disease (PD). OBJECTIVE: To explore the association between GCase activity, PD phenotype, and probability for prodromal PD among carriers of mutations in the GBA and LRRK2 genes. METHODS: Participants were genotyped for the G2019S-LRRK2 and nine GBA mutations common in Ashkenazi...

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Identifiers

PMID: 34550621
DOI: 10.1002/mds.28792
PMCID: PMC9292990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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