Article
β-Glucocerebrosidase activity in GBA-linked Parkinson disease: The type of mutation matters.
Neurology - 11 Aug 2020
Huh Young Eun, Chiang Ming Sum Ruby, Locascio Joseph J, Liao Zhixiang, Liu Ganqiang, Choudhury Karbi, Kuras Yuliya I, Tuncali Idil, Videnovic Aleksandar, Hunt Ann L, Schwarzschild Michael A, Hung Albert Y, Herrington Todd M, Hayes Michael T, Hyman Bradley T, Wills Anne-Marie, Gomperts Stephen N, Growdon John H, Sardi Sergio Pablo, Scherzer Clemens R
Abstract excerpt
OBJECTIVE: To test the relationship between clinically relevant types of GBA mutations (none, risk variants, mild mutations, severe mutations) and β-glucocerebrosidase activity in patients with Parkinson disease (PD) in cross-sectional and longitudinal case-control studies. METHODS: A total of 481 participants from the Harvard Biomarkers Study (HBS) and the NIH Parkinson's Disease Biomarkers Program (PDBP) were...
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