Article
A Biomarker Study in Patients with GBA1-Parkinson's Disease and Healthy Controls.
Movement disorders : official journal of the Movement Disorder Society - 1 May 2023
den Heijer Jonas M, Cullen Valerie C, Pereira Diana R, Yavuz Yalcin, de Kam Marieke L, Grievink Hendrika W, Moerland Matthijs, Leymarie Nancy, Khatri Kshitij, Sollomoni Imelda, Spitalny Leslie, Dungeon Lindsay, Hilt Dana C, Justman Craig, Lansbury Peter, Groeneveld Geert Jan
Abstract excerpt
BACKGROUND: Molecules related to glucocerebrosidase (GCase) are potential biomarkers for development of compounds targeting GBA1-associated Parkinson's disease (GBA-PD). OBJECTIVES: Assessing variability of various glycosphingolipids (GSLs) in plasma, peripheral blood mononuclear cells (PBMCs), and cerebrospinal fluid (CSF) across GBA-PD, idiopathic PD (iPD), and healthy volunteers (HVs). METHODS: Data from five...
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