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Article

Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity.

Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2021

Ysselstein Daniel, Young Tiffany J, Nguyen Maria, Padmanabhan Shalini, Hirst Warren D, Dzamko Nicolas, Krainc Dimitri

Abstract excerpt

Mutations in GBA1, which encode for the protein glucocerebrosidase (GCase), are the most common genetic risk factor for Parkinson's disease and dementia with Lewy bodies. In addition, growing evidence now suggests that the loss of GCase activity is also involved in onset of all forms of Parkinson's disease, dementia with Lewy bodies, and other dementias, such as progranulin-linked frontal temporal dementia. As a...

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Identifiers

PMID: 34613624
DOI: 10.1002/mds.28815
PMCID: PMC8853444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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