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Article

Association of CSF Glucocerebrosidase Activity With the Risk of Incident Dementia in Patients With Parkinson Disease.

Neurology - 24 Jan 2023

Oftedal Linn, Maple-Grødem Jodi, Dalen Ingvild, Tysnes Ole-Bjørn, Pedersen Kenn Freddy, Alves Guido, Lange Johannes

Abstract excerpt

BACKGROUND AND OBJECTIVES: Variations in the glucocerebrosidase gene (GBA) are common risk factors for Parkinson disease (PD) and dementia in PD (PDD) and cause a reduction in the activity of the lysosomal enzyme glucocerebrosidase (GCase). It is anticipated that GCase dysfunction might contribute to a more malignant disease course and predict cognitive impairment in PD, although evidence is lacking. We aimed to...

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Identifiers

PMID: 36253102
DOI: 10.1212/WNL.0000000000201418
PMCID: PMC9897053

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