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Article

Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression.

JAMA network open - 1 Apr 2021

Ortega Roberto A, Wang Cuiling, Raymond Deborah, Bryant Nicole, Scherzer Clemens R, Thaler Avner, Alcalay Roy N, West Andrew B, Mirelman Anat, Kuras Yuliya, Marder Karen S, Giladi Nir, Ozelius Laurie J, Bressman Susan B, Saunders-Pullman Rachel

Abstract excerpt

Importance: Despite a hypothesis that harboring a leucine-rich repeat kinase 2(LRRK2) G2019S variation and a glucocerebrosidase (GBA) variant would have a combined deleterious association with disease pathogenesis, milder clinical phenotypes have been reported in dual LRRK2 and GBA variations Parkinson disease (PD) than in GBA variation PD alone. Objective: To evaluate the association of LRRK2 G2019S and GBA...

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Source

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Identifiers

PMID: 33881531
DOI: 10.1001/jamanetworkopen.2021.5845
PMCID: PMC8060834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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