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Article

TDP-43-mediated neuron loss in vivo requires RNA-binding activity.

PloS one - 18 Aug 2010

Voigt Aaron, Herholz David, Fiesel Fabienne C, Kaur Kavita, Müller Daniel, Karsten Peter, Weber Stephanie S, Kahle Philipp J, Marquardt Till, Schulz Jörg B

Abstract excerpt

Alteration and/or mutations of the ribonucleoprotein TDP-43 have been firmly linked to human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The relative impacts of TDP-43 alteration, mutation, or inherent protein function on...

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Identifiers

PMID: 20806063
DOI: 10.1371/journal.pone.0012247
PMCID: PMC2923622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20806063-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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