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DEVOLUTION-A method for phylogenetic reconstruction of aneuploid cancers based on multiregional genotyping data.

Communications biology - 20 Sept 2021

Andersson Natalie, Chattopadhyay Subhayan, Valind Anders, Karlsson Jenny, Gisselsson David

Abstract excerpt

Phylogenetic reconstruction of cancer cell populations remains challenging. There is a particular lack of tools that deconvolve clones based on copy number aberration analyses of multiple tumor biopsies separated in time and space from the same patient. This has hampered investigations of tumors rich in aneuploidy but few point mutations, as in many childhood cancers and high-risk adult cancer. Here, we present...

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PMID: 34545199
DOI: 10.1038/s42003-021-02637-6
PMCID: PMC8452746

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