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Article

Tracing the evolution of aneuploid cancers by multiregional sequencing with CRUST.

Briefings in bioinformatics - 5 Nov 2021

Chattopadhyay Subhayan, Karlsson Jenny, Valind Anders, Andersson Natalie, Gisselsson David

Abstract excerpt

Clonal deconvolution of mutational landscapes is crucial to understand the evolutionary dynamics of cancer. Two limiting factors for clonal deconvolution that have remained unresolved are variation in purity and chromosomal copy number across different samples of the same tumor. We developed a semi-supervised algorithm that tracks variant calls through multi-sample spatiotemporal tumor data. While normalizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34343239
DOI: 10.1093/bib/bbab292
PMCID: PMC8981300

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