Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic evolution and the impact of SLIT2 mutation in relapsed intrahepatic cholangiocarcinoma.

Hepatology (Baltimore, Md.) - 1 Apr 2022

Zhou Shao-Lai, Luo Chu-Bin, Song Cheng-Li, Zhou Zheng-Jun, Xin Hao-Yang, Hu Zhi-Qiang, Sun Rong-Qi, Fan Jia, Zhou Jian

Abstract excerpt

BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma (ICC) is aggressive and has high rates of relapse, conferring poor long-term survival after curative resection. Little is known about the genomic evolution that occurs during ICC relapse. APPROACH AND RESULTS: We conducted whole-exome sequencing of 30 paired primary and relapsed tumors from 10 patients with ICC who received curative resection. We sought to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bile Duct Neoplasms
Share to Cholangiocarcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Intercellular Signaling Peptides and Proteins

Share to Neoplasm Recurrence, Local

Share to Nerve Tissue Proteins

Share to Phosphatidylinositol 3-Kinases

Share to Tumor Microenvironment

Source

Identifiers

PMID: 34543483
DOI: 10.1002/hep.32164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic evolution and the impact of SLIT2 mutation in relapsed intrahepatic cholangiocarcinoma.PMID 34543483Read ↗

Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations.Semantic proximity Read ↗

Inactivating LATS2 variation drives tumor progression and resistance to anti-PD-1 therapy in intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Cancer evolution and multi-omic profile of relapsed colorectal liver metastases after treatment.Semantic proximity Read ↗

Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma.Semantic proximity Read ↗

Multiple cellular origins and molecular evolution of intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Next-generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal-type sinonasal adenocarcinoma.Semantic proximity Read ↗

Comprehensive analysis of genomic mutation signature and tumor mutation burden for prognosis of intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma.Semantic proximity Read ↗

Mutational dynamics between primary and relapse neuroblastomas.Semantic proximity Read ↗

Mutations acquired by hepatocellular carcinoma recurrence give rise to an aggressive phenotype.Semantic proximity Read ↗

Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.