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Article

Mutations acquired by hepatocellular carcinoma recurrence give rise to an aggressive phenotype.

Oncotarget - 4 Apr 2017

Choi Ji-Hye, Kim Min Jae, Park Yong Keun, Im Jong-Yeop, Kwon So Mee, Kim Hyung Chul, Woo Hyun Goo, Wang Hee-Jung

Abstract excerpt

Recurrence of hepatocellular carcinoma (HCC) even after curative resection causes dismal outcomes of patients. Here, to delineate the driver events of genomic and transcription alteration during HCC recurrence, we performed RNA-Seq profiling of the paired primary and recurrent tumors from two patients with intrahepatic HCC. By comparing the mutational and transcriptomic profiles, we identified somatic mutations...

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Topics

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Share to Carcinoma, Hepatocellular
Share to CXCL8 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms

Share to Neoplasm Recurrence, Local

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Source

Open in PubMed Open full text

Identifiers

PMID: 28038442
DOI: 10.18632/oncotarget.14248
PMCID: PMC5410272

Genes

GOLGB1
CXCL8
SOX4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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