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Article

Comprehensive analysis of genomic mutation signature and tumor mutation burden for prognosis of intrahepatic cholangiocarcinoma.

BMC cancer - 3 Feb 2021

Zhang Rui, Li Qi, Fu Jialu, Jin Zhechuan, Su Jingbo, Zhang Jian, Chen Chen, Geng Zhimin, Zhang Dong

Abstract excerpt

BACKGROUND: Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal malignancy of the biliary tract. Analysis of somatic mutational profiling can reveal new prognostic markers and actionable treatment targets. In this study, we explored the utility of genomic mutation signature and tumor mutation burden (TMB) in predicting prognosis in iCCA patients. METHODS: Whole-exome sequencing and corresponding clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33535978
DOI: 10.1186/s12885-021-07788-7
PMCID: PMC7860034

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