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Article

Mutational dynamics between primary and relapse neuroblastomas.

Nature genetics - 1 Aug 2015

Schramm Alexander, Köster Johannes, Assenov Yassen, Althoff Kristina, Peifer Martin, Mahlow Ellen, Odersky Andrea, Beisser Daniela, Ernst Corinna, Henssen Anton G, Stephan Harald, Schröder Christopher, Heukamp Lukas, Engesser Anne, Kahlert Yvonne, Theissen Jessica, Hero Barbara, Roels Frederik, Altmüller Janine, Nürnberg Peter, Astrahantseff Kathy, Gloeckner Christian, De Preter Katleen, Plass Christoph, Lee Sangkyun, Lode Holger N, Henrich Kai-Oliver, Gartlgruber Moritz, Speleman Frank, Schmezer Peter, Westermann Frank, Rahmann Sven, Fischer Matthias, Eggert Angelika, Schulte Johannes H

Abstract excerpt

Neuroblastoma is a malignancy of the developing sympathetic nervous system that is often lethal when relapse occurs. We here used whole-exome sequencing, mRNA expression profiling, array CGH and DNA methylation analysis to characterize 16 paired samples at diagnosis and relapse from individuals with neuroblastoma. The mutational burden significantly increased in relapsing tumors, accompanied by altered mutational...

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Source

Identifiers

PMID: 26121086
DOI: 10.1038/ng.3349

Genes

PTPN14
CHD5
DOCK8
HRAS
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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