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Article

Cancer evolution and multi-omic profile of relapsed colorectal liver metastases after treatment.

Genome medicine - 24 Feb 2026

Tomás Laura, Raschzok Nathanael, Blanc Eric, Gallardo-Gómez María, Menne Andrea, Astrahantseff Kathy, De Chiara Loretta, Geisel Dominik, Pratschke Johann, Modest Dominik P, Eggert Angelika, Beule Dieter, Posada David, Sers Christine, Mamlouk Soulafa

Abstract excerpt

BACKGROUND: Recurrence following resection of colorectal cancer liver metastases remains a major obstacle to prolonged patient survival, often resulting in treatment-refractory disease with limited understanding of the underlying evolutionary drivers. To investigate these mechanisms, we performed an in-depth, patient-specific study of genomic and microenvironmental alterations in relapsed colorectal cancer liver...

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Share to Clonal Evolution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver Neoplasms

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Share to Neoplasm Recurrence, Local

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Source

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Identifiers

PMID: 41736133
DOI: 10.1186/s13073-026-01614-0
PMCID: PMC12980905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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