Article
Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients.
Gastroenterology - 1 May 2014
Gao Qiang, Zhao Ying-Jun, Wang Xiao-Ying, Guo Wei-Jie, Gao Song, Wei Lin, Shi Jie-Yi, Shi Guo-Ming, Wang Zhi-Chao, Zhang Yuan-Nv, Shi Ying-Hong, Ding Jie, Ding Zhen-Bin, Ke Ai-Wu, Dai Zhi, Wu Fei-Zhen, Wang Hui, Qiu Zhao-Ping, Chen Zhi-Ao, Zhang Zhen-Feng, Qiu Shuang-Jian, Zhou Jian, He Xiang-Huo, Fan Jia
Abstract excerpt
BACKGROUND & AIMS: The pathogenesis of intrahepatic cholangiocarcinoma (ICC), the second most common hepatic cancer, is poorly understood, and the incidence of ICC is increasing worldwide. We searched for mutations in human ICC tumor samples and investigated how they affect ICC cell function. METHODS: We performed whole exome sequencing of 7 pairs of ICC tumors and their surrounding nontumor tissues to detect...
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