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Article

Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma.

Journal of hepatology - 1 Jul 2018

Dong Liang-Qing, Shi Yang, Ma Li-Jie, Yang Liu-Xiao, Wang Xiao-Ying, Zhang Shu, Wang Zhi-Chao, Duan Meng, Zhang Zhao, Liu Long-Zi, Zheng Bo-Hao, Ding Zhen-Bin, Ke Ai-Wu, Gao Da-Ming, Yuan Ke, Zhou Jian, Fan Jia, Xi Ruibin, Gao Qiang

Abstract excerpt

BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (ICC) is the second-most lethal primary liver cancer. Little is known about intratumoral heterogeneity (ITH) and its impact on ICC progression. We aimed to investigate the ITH of ICC in the hope of helping to develop new therapeutic strategies. METHODS: We obtained 69 spatially distinct regions from six operable ICCs. Patient-derived primary cancer cells (PDPCs)...

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Share to Bile Duct Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholangiocarcinoma

Share to Chromosomal Instability

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Source

Identifiers

PMID: 29551704
DOI: 10.1016/j.jhep.2018.02.029

Genes

EGFR
IDH1
JAK1
KRAS
PBRM1
SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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