Article
Next-generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal-type sinonasal adenocarcinoma.
Head & neck - 1 Aug 2024
Riobello Cristina, Sánchez-Fernández Paula, Córdoba María Camila Cubides, González-Gutiérrez Maripaz, Vivanco Blanca, Cabal Virginia N, Fernández Laura Suárez, García-Marín Rocío, Codina-Martínez Helena, Lorenzo-Guerra Sara Lucila, López Fernando, Hermsen Mario A, Llorente José Luis
Abstract excerpt
BACKGROUND: Recurrent intestinal-type sinonasal adenocarcinoma (ITAC) can occur several years after primary treatment and with different histology. We aimed to clarify if such recurrences could be second primary tumors and to identify actionable mutations as targets for personalized treatment of recurrent ITAC. METHODS: Twelve pairs of primary and recurrent ITAC were histologically examined and analyzed by...
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