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Article

Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma.

Nature communications - 1 Mar 2018

Wang Anqiang, Wu Liangcai, Lin Jianzhen, Han Longzhe, Bian Jin, Wu Yan, Robson Simon C, Xue Lai, Ge Yunxia, Sang Xinting, Wang Wenze, Zhao Haitao

Abstract excerpt

Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with clinicopathological features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). To date, molecular mechanisms underlying the co-existence of HCC and iCCA components in a single tumor remain elusive. Here, we show that H-ChC samples contain substantial private mutations from WES analyses, ranging from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29497050
DOI: 10.1038/s41467-018-03276-y
PMCID: PMC5832792

Genes

FCGBP
VCAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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