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Article

Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations.

Oncotarget - 26 Apr 2016

Kim Young-Ho, Hong Eun-Kyung, Kong Sun-Young, Han Sung-Sik, Kim Seoung-Hoon, Rhee Je-Keun, Hwang Soo-Kyung, Park Sang-Jae, Kim Tae-Min

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is a biliary tree-origin epithelial malignancy in liver with unfavorable clinical outcomes. Systematic genome analyses may advance our understanding of ICC pathogenesis also improving current diagnostic and therapeutic modalities. In this study, we analyzed 17 ICC tumor-vs-matched normal pairs using either whole-exome (n = 7), transcriptome sequencing (n = 7) or both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27009864
DOI: 10.18632/oncotarget.8183
PMCID: PMC5029666

Genes

APC
KRAS
ROBO1
ROBO2
RUNX3
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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