Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective Upregulation of CTLA-4 on CD8+ T Cells Restricted by HLA-B*35Px Renders them to an Exhausted Phenotype in HIV-1 infection.

PLoS pathogens - 1 Aug 2020

Elahi Shokrollah, Shahbaz Shima, Houston Stan

Abstract excerpt

HLA-B*35Px is associated with HIV-1 disease rapid progression to AIDS. However, the mechanism(s) underlying this deleterious effect of this HLA allele on HIV-1 infection outcome has not fully understood. CD8+ T cells play a crucial role to control the viral replication but impaired CD8+ T cells represent a major hallmark of HIV-1 infection. Here, we examined the effector functions of CD8+ T cells restricted by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to CTLA-4 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA-B35 Antigen

Share to Leukocytes, Mononuclear

Share to Lymphocyte Activation

Share to T-Lymphocytes, Regulatory

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 32760139
DOI: 10.1371/journal.ppat.1008696
PMCID: PMC7410205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective Upregulation of CTLA-4 on CD8+ T Cells Restricted by HLA-B*35Px Renders them to an Exhausted Phenotype in HIV-1 infection.PMID 32760139Read ↗

Protective HIV-specific CD8+ T cells evade Treg cell suppression.Semantic proximity Read ↗

Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.Semantic proximity Read ↗

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen loadSemantic proximity Read ↗

Protective HLA Alleles Recruit Biased and Largely Similar Antigen-Specific T Cell Repertoires across Different Outcomes in HIV Infection.Semantic proximity Read ↗

Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.Semantic proximity Read ↗

Immunological Control of HIV-1 Disease Progression by Rare Protective HLA Allele.Semantic proximity Read ↗

HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.Semantic proximity Read ↗

HIV type 1-mediated downregulation of HLA-B*57/B*5801 proteins on elite suppressor CD4+ T cells.Semantic proximity Read ↗

HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control.Semantic proximity Read ↗

Collaboration of a Detrimental HLA-B*35:01 Allele with HLA-A*24:02 in Coevolution of HIV-1 with T Cells Leading to Poorer Clinical Outcomes.Semantic proximity Read ↗

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.Semantic proximity Read ↗

HIV: current opinion in escapology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.