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Article

Critical effect of Pol escape mutations associated with detrimental allele HLA-C*15: 05 on clinical outcome in HIV-1 subtype A/E infection.

AIDS (London, England) - 1 Jan 2021

Murakoshi Hayato, Chikata Takayuki, Akahoshi Tomohiro, Zou Chengcheng, Borghan Mohamed Ali, Van Tran Giang, Nguyen Trung Vu, Van Nguyen Kinh, Kuse Nozomi, Takiguchi Masafumi

Abstract excerpt

OBJECTIVE: The mechanism explaining the role of detrimental HLA alleles in HIV-1 infections has been investigated in very few studies. HLA-A*29:01-B*07:05-C*15:05 is a detrimental haplotype in HIV-1 subtype A/E-infected Vietnamese individuals. The accumulation of mutations at Pol 653/657 is associated with a poor clinical outcome in these individuals. However, the detrimental HLA allele and the mechanism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33031103
DOI: 10.1097/QAD.0000000000002704
PMCID: PMC7752225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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